Recombinant Mouse FZD2 (C-Fc)

Description

EnkiLife provides the Recombinant Mouse FZD2 (C-Fc) protein,aslo know as Frizzled-2,Fz-2,mFz2,Fzd2;frizzled (Drosophila) homolog 2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Frizzled (Drosophila) Homolog 2 is produced by our Mammalian expression system and the target gene encoding Gln29-Leu168 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:Q9JIP6. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:42.9 KDa. Background:Wnt signaling plays a critical role in embryonic development, and genetic aberrations. Frizzled2 (Fzd2) is a receptor for wingless-type MMTV integration site family members (Wnts), the aberrant overexpression of which has been noted to contribute to cancer metastasis. Frizzled2 (Fzd2) and its ligands Wnt5a/b are elevated in metastatic liver, lung, colon, and breast cancer cell lines and in high-grade tumors and that their expression correlates with markers of epithelial-mesenchymal transition (EMT). It is also shown that Frizzled-2 expression is greater in embryonic than adult tissues, with heart, brain, lung, kidney and gut showing the highest levels.