Recombinant Mouse GDF15 (N-8His-Flag)

Description

EnkiLife provides the Recombinant Mouse GDF15 (N-8His-Flag) protein,aslo know as Growth Differentiation Factor/xa015, Macrophage inhibitory cytokine 1, GDF-15, MIC-1, NAG-1, PLAB, PTGFB, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Growth Differentiation Factor/xa015 is produced by our Mammalian expression system and the target gene encoding Ser189-Ala303 is expressed with a 8His, Flag tag at the N-terminus.Accession:Q9Z0J7. Expression Host:Human cells.Species:Mouse.Predicted Molecular Mass:16.9 KDa. Background:Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be secreted by a wide variety of cell types in response to a broad range of stressors. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. GDF15 was shown to inhibit proliferation of primitive hematopoietic progenitors and introduced as a putative placental mediator of embryonic development. GDF15 has recently gained scientific and translational prominence with the discovery that its receptor is a GFRAL-RET heterodimer of which GFRAL is expressed solely in the hindbrain.