Recombinant Mouse HVEM (C-Fc)

Description

EnkiLife provides the Recombinant Mouse HVEM (C-Fc) protein,aslo know as Tnfrsf14,Herpesvirus entry mediator,HVEM,TR2,TNF receptor-like molecule,ATAR,another TRAF-associated receptor,Tumor necrosis factor receptor superfamily member 14, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Herpesvirus Entry Mediator is produced by our Mammalian expression system and the target gene encoding Gln39-Val207 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:Q80WM9. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:45.47 KDa. Background:Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. It has demonstrated that HVEM Ig is able to exert a significant antiviral effect against HSV-1 infection in vivo.