Recombinant Mouse ICAM-2 (C-Fc)

Description

EnkiLife provides the Recombinant Mouse ICAM-2 (C-Fc) protein,aslo know as Intercellular adhesion molecule 2,Icam2,ICAM-2,Lymphocyte function-associated AG-1 counter-receptor,CD102,Icam-2,CD102 antigen, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Intercellular Adhesion Molecule 2 is produced by our Mammalian expression system and the target gene encoding Lys23-Gln222 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:P35330. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:49.7 KDa. Background:ICAM-2 is a 55-65 kD transmembrane glycoprotein possessing 2 extracellular Ig domains, a single transmembrane domain, and a short 26-amino acid cytoplasmic domain. ICAM-2 is expressed on most leukocytes, and is strongly expressed on vascular endothelial cells. Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocytewith other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc. Serum levels of ICAM-2 correlated significantly with the inflammatory and course sequences of trichinosis in mice and had a similar relation with blood eosinophilia. So, estimation of ICAM-2 serum levels may prove useful in diagnosis of trichinosis recent infections, and in monitoring the prognosis and response to treatment.