Recombinant Mouse ICOS (C-6His)

Description

EnkiLife provides the Recombinant Mouse ICOS (C-6His) protein,aslo know as Inducible T-cell costimulator,Activation-inducible lymphocyte immunomediatory molecule,CD28 and CTLA-4-like protein,CCLP, CD28-related protein 1,CRP-1,CD278,Icos,Ailim, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Inducible T-cell Costimulator is produced by our Mammalian expression system and the target gene encoding Glu21-Leu142 is expressed with a 6His tag at the C-terminus.Accession:Q9WVS0. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:14.7 KDa. Background:Inducible Costimulator(ICOS) is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA4 and PD1. ICOS shares approximately 39% amino acid similarity with CD 28 and CTLA4. Mouse and human ICOS share approximately 72% amino acid identity. ICOS is expressed on most CD45RO+ cells. ICOS expression is up-regulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. In addition, ICOS is more potent in the induction of IL-10 production, acytokine important for suppressive function of T regulatory cells.