Recombinant Mouse IFNGR1 (C-6His)

Description

EnkiLife provides the Recombinant Mouse IFNGR1 (C-6His) protein,aslo know as CD119,Interferon gamma receptor 1,IFNGR1,IFN-gamma receptor 1,IFN-gamma-R1,CD119 antigen,IFN gamma receptor 1,IFNGR,immune interferon receptor 1,interferon gamma receptor 1,interferon-gamma receptor alpha chain, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Interferon Gamma Receptor 1 is produced by our Mammalian expression system and the target gene encoding Ala26-Asp253 is expressed with a 6His tag at the C-terminus.Accession:P15261. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:26.9 KDa. Background:The tetrameric receptor complex for IFNγ consists of two subunits, IFNGR1 (IFNγ Rα) and IFNGR2 (IFNγ Rβ), through which the dimeric IFN-γ exerts its biological functions, including antiviral, antiproliferation and immune-modulatory activity in mammals. Both IFNGR1 and IFNGR2 are single transmembrane proteins belonging to the class II cytokine family. FNGR1, widely expressed in most host cells, is essential for IFNγ binding, receptor trafficking, and signal transduction. IFNGR1 possesses an intracellular Janus tyrosine kinase (JAK) 1 binding site, a signal transducer and activator of transcription 1 (STAT1) binding site. The resulting STAT1 homodimers translocate from the cytoplasm to the nucleus and bind to the interferon-gamma activated sequence (GAS) promoter to induce expression of downstream interferon stimulated genes (ISGs).