Recombinant Mouse IL-11RA (C-6His)

Description

EnkiLife provides the Recombinant Mouse IL-11RA (C-6His) protein,aslo know as IL-11 R alpha,IL11R alpha,IL11RA,IL-11Ra,Il11ra2,NR1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Interleukin-11 Receptor Subunit Alpha-1 is produced by our Mammalian expression system and the target gene encoding Ser24-Gln367 is expressed with a 6His tag at the C-terminus.Accession:Q64385. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:38.5 KDa. Background:Interleukin 11 receptor alpha (IL 11 R alpha, IL 11 R alpha 1) originally designated NR1 in mouse, is a 49 kDa type I transmembrane protein that is a member of the gp130 subfamily of the hematopoietic cytokine receptor family. IL-11 R alpha first binds IL 11 with low affinity, then forms a high affinity receptor when complexed with gp130 homodimers. IL 11 R alpha is also anti-apoptotic for colonic epithelia, and increased IL 11 signaling may be a factor in inflammation-associated gastrointestinal cancer development. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth.A soluble form (sIL11RA) can act as an antagonist of IL11-dependent cell differentiation in cells where both transmembrane IL11RA and IL6ST are present.