Recombinant Mouse IL-17RB (C-6His)

Description

EnkiLife provides the Recombinant Mouse IL-17RB (C-6His) protein,aslo know as Evi27,EVI27IL-17B receptor,IL-17 RB,IL-17 receptor B,IL-17 RH1,IL-17ER,IL17Rh1,IL-17Rh1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Interleukin-17 Receptor B is produced by our Mammalian expression system and the target gene encoding Arg18-Gly286 is expressed with a 6His tag at the C-terminus.Accession:Q9JIP3. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:30.6 KDa. Background:Interleukin-17B Receptor (IL-17B R), also known as IL-17 Rh1, IL-17E R and EVI27, represents the second receptor of the IL-17 family cytokines to be recognized. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and the short survival of breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in cell growth, proliferation, and migration through the activation of NF-kappaB as well as the up-regulation of the Bcl-2. IL17RB may be the only gene expressed in CD4+ T cells whose transcript measurement is correlated with the variation in IgE level in asthmatics. Diseases associated with IL17RB include Chronic Mucocutaneous Candidiasis and Seborrheic Infantile Dermatitis.