Recombinant Mouse IL-18BPd (C-Fc)

Description

EnkiLife provides the Recombinant Mouse IL-18BPd (C-Fc) protein,aslo know as Interleukin 18 Binding Protein Isoform d,IL-18 BPd;Interleukin-18-binding protein;Interferon gamma-inducing factor-binding protein;Igifbp, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Interleukin-18 Binding Protein Isoform d is produced by our Mammalian expression system and the target gene encoding Thr29-Ala193 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:Q9Z0M9. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:45.1 KDa. Background:Interleukin 18 binding protein (IL-18BP) is a physiological inhibitor that acts through binding to the receptor-binding site of IL-18. IL-18 stimulates INF-γ, which then stimulates 18BP production via NF-κB. The interaction between IL-18 and IL-18BP has a significant role in the inflammation process. IL-18 BPs have four isoforms, a, b, c and d, which are spliced by different ways. The IL-18 BP isoforms a and c each contain one immunoglobulin (Ig)-like C2-type domain which is essential to the binding and neutralizing properties of the binding proteins. The IL-18 BP isoforms b and d lack a complete Ig domain. The expression of IL-18 and the IL-18BP are indentified in immune tissues such as the spleen, but also in nonimmune cells including keratinocytes.