Recombinant Mouse IL-22 (E. coli)

Description

EnkiLife provides the Recombinant Mouse IL-22 (E. coli) protein,aslo know as Interleukin-22,IL-22,IL-10-Related T-Cell-Derived-Inducible Factor,IL-TIF,IL-TIF Alpha,Interleukin-22a,IL-22a,Il22,Il22a,Iltif,Iltifa, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<0.01 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Interleukin-22 is produced by our E.coli expression system and the target gene encoding Leu34-Val179 is expressed.Accession:Q9JJY9. Expression Host:E.coli.Species:Mouse.Predicted Molecular Mass:16.7 KDa. Background:Interleukin-22 (IL-22) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Mouse IL-22 cDNA encodes a 179 amino acid residue protein with a putative 33 amino acid signal peptide that is cleaved to generate a 147 amino acid mature protein that shares approximately 79% and 22% sequence identity with human IL22 and IL10, respectively. IL22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and up-regulate the production of acute phase proteins. IL-22 is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10Rβ (previously known as CRF2-4), belonging to the class II cytokine receptor family.