Recombinant Mouse IL17 (E. coli)

Description

Interleukin-17 IL-17 or IL-17A is the founder member of the IL-17 cytokine family, which shares 50 % homology with IL-17F. IL-17 cytokines are produced by T helper TH 17 cells, gamma delta T cells, and other immune cells. IL-17A and IL-17F form homodimers and heterodimers as functional ligands. IL-17 cytokines bind to two receptors, IL-17RA and IL-17RC. IL-17RC forms a receptor heterodimer with IL-17RA. The receptor heterodimer is preferred by IL-17 ligands, thus, either IL-17RA knockout KO or IL-17RC KO completely abolishes IL-17 signaling. IL-17A and IL-17F are key proinflammatory cytokines involved in many inflammatory and autoimmune diseases.