Recombinant Mouse LMIR1 (C-Fc)

Description

EnkiLife provides the Recombinant Mouse LMIR1 (C-Fc) protein,aslo know as CD300a;CD300a antigen;CMRF35H9,CD300a molecule,leukocyte immunoglobulin-like receptor;CD300 antigen-like family member A,CMRF35-like molecule 8;NK inhibitory receptor,Immunoglobulin superfamily member 12,IRp60;Inhibitory receptor protein 60,CLM8,CMRF-35H,IGSF12,IRC1,IRC2, LMIR1;CLM-8;MAIR-I, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Leukocyte Mono-Ig-like Receptor 1 is produced by our Mammalian expression system and the target gene encoding Leu28-Arg183 is expressed with a human IgG1 Fc tag at the C-terminus.Accession:Q6SJQ0. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:44.3 KDa. Background:LMIR1, also termed CD300a, is a type I transmembrane glycoprotein with a single IgV-like extracellular domain and an extended membrane proximal region that links the immunoglobulin (Ig) and transmembrane domains and belongs to the immunoglobulin superfamily. The intracellular domain of LMIR1 contains several immunoreceptor tyrosine-based inhibition motifs (ITIMs). When cross-linked, it will be tyrosine phosphorylated and capable of recruiting tyrosine phosphatases (SHP-1, SHP-2) and inositol polyphosphate 5-phosphatase, SHIP. LMIR1 will regulate mast cell-mediated inflammatory responses. LMIR1 is broadly expressed on myeloid and lymphoid cells, and its expression is differentially regulated depending on the cell type.