Recombinant Mouse Pleiotrophin (C-6His)

Description

EnkiLife provides the Recombinant Mouse Pleiotrophin (C-6His) protein,aslo know as Pleiotrophin,PTN,Heparin-binding brain mitogen,HBBM,Heparin-binding growth factor 8,HBGF-8,Osteoblast-specific factor 1,OSF-1;, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Pleiotrophin is produced by our Mammalian expression system and the target gene encoding Gly33-Asp168 is expressed with a 6His tag at the C-terminus.Accession:P63089. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:16.1 KDa. Background:Pleiotrophin (PTN) is a secreted, strongly heparinbinding, developmentally regulated cytokine. PTN is a highly conserved protein，Human, mouse, rat, canine, porcine, equine and bovine PTN share 98% aa sequence identity or greater. PTN and midkine share 50% amino acid (aa) sequence identity, share some functions, and constitute a family. During development, PTN is involved in development of brain, bone, and organs undergoing branching morphogenesis. PTN causes PTPRB dimerization and inactivates its phosphatase activity, which allows increased tyrosine phosphorylation of its substrates. Increased expression of PTN is correlated with neuronal development or stresses such as brain ischemia and Parkinson’s disease.