Recombinant Mouse PTX3 (N-6His)

Description

EnkiLife provides the Recombinant Mouse PTX3 (N-6His) protein,aslo know as alpha-induced protein 5,pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor,Pentaxin-related protein PTX3,Pentraxin 3,pentraxin 3, long,pentraxin-3,pentraxin-related gene, rapidly induced by IL-1 beta,pentraxin-related protein PTX3,PTX3,TNF alpha-induced protein 5,TNFAIP5,TSG14,TSG-14, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Pentraxin-related protein PTX3 is produced by our Mammalian expression system and the target gene encoding Glu18-Ser381 is expressed with a 6His tag at the N-terminus.Accession:P48759. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:43.4 KDa. Background:Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator of immune response. PTX3 may also function in the regulation of the uptake and clearance of apoptotic cells by dendritic cells. An in vivo study showed that PTX3 transgenic mice are more resistant to sepsis and endotoxemia compared to wild-type during inflammatory injury.