Recombinant Mouse Siglec-15 (C-6His)

Description

EnkiLife provides the Recombinant Mouse Siglec-15 (C-6His) protein,aslo know as Sialic acid-binding Ig-like lectin 15,Siglec-15,CD33 antigen-like 3,CD33L3, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Sialic Acid-binding Ig-like Lectin 15 is produced by our Mammalian expression system and the target gene encoding Arg24-Thr262 is expressed with a 6His tag at the C-terminus.Accession:A7E1W8. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:26.5 KDa. Background:Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts