Recombinant Mouse SLAMF5 (C-6His)

Description

EnkiLife provides the Recombinant Mouse SLAMF5 (C-6His) protein,aslo know as SLAM family member 5,Cd84,Leukocyte differentiation antigen CD84,Signaling lymphocytic activation molecule 5,CD84,Ly-9B,SLAMF5,CD84 antigen,CD84 molecule,SLAM family member 5, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse SLAM Family Member 5 is produced by our Mammalian expression system and the target gene encoding Lys22-Pro223 is expressed with a 6His tag at the C-terminus.Accession:AAD02273.1. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:23.8 KDa. Background:CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based switch motifs (ITSM) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. CD84 expression has been documented on several hematopoietic cell types, including monocytes, macrophages, dendritic cells, B lymphocytes, and platelets. Activation of cell surface CD84 initiates a signaling cascade involving its intra-cytoplasmic tyrosine residues that results in Bcl-2 upregulation, which in turn enhances cell survival. Either immunoneutralization or blockade of CD84 with a CD84 extracellular domain protein fragment induces cell death in vitro and in vivo.