Recombinant Mouse ST2 (C-6His)

Description

EnkiLife provides the Recombinant Mouse ST2 (C-6His) protein,aslo know as Interleukin-1 receptor-like 1,Lymphocyte antigen 84,Protein ST2,Protein T1,Il1rl1,DER4,Fit-1,IL-1 R4,IL-1RL1,IL-33R,Ly84,ST2L,ST2V,suppression of tumorigenicity 2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Interleukin-1 Receptor-like 1 is produced by our Mammalian expression system and the target gene encoding Ser27-Ala337 is expressed with a 6His tag at the C-terminus.Accession:P14719-2. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:36.6 KDa. Background:ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor α chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2). ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity.