Recombinant Mouse TF (C-6His)

Description

EnkiLife provides the Recombinant Mouse TF (C-6His) protein,aslo know as Tissue factor,TF,Coagulation factor III, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Tissue Factor is produced by our Mammalian expression system and the target gene encoding Ala29-Glu251 is expressed with a 6His tag at the C-terminus.Accession:P20352. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:26.2 KDa. Background:Tissue/xa0Factor, also known as thromboplastin and CD142,/xa0belongs to the tissue factor family which conteins 294 amino acid (aa). Mouse TF consists of a signal peptide (residues 1-28) and the mature chain (residues 29-294). It is a single-pass type I membrane protein that expressed in the liver oscillates in a circadian manner. Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.