Recombinant Mouse TGFBR3 (C-6His)

Description

EnkiLife provides the Recombinant Mouse TGFBR3 (C-6His) protein,aslo know as BGCAN,TBRIII,TGF-beta receptor type 3,TGF-beta receptor type III,TGF-beta RIII,TGFbetaRIII,TGFBR3,TGF-bRIII,TGFR-3,Transforming growth factor beta receptor III, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Transforming Growth Factor Beta Receptor Type 3 is produced by our Mammalian expression system and the target gene encoding Gly23-Thr785 is expressed with a 6His tag at the C-terminus.Accession:A0A0R4J097. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:85.9 KDa. Background:Transforming growth factor beta receptor III (TGF-beta RIII; also betaglycan) is a ubiquitously expressed, 280 kDa type I transmembrane proteoglycan member of the TGF-beta superfamily of proteins. This receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. TGF-beta RIII can enhance or inhibit cell signaling. TGF-beta RIII has been shown to play an essential role in the formation of the atrioventricular cushion and coronary vessels during development of the heart. TGF beta RIII also plays a role in many cancers. Increased expression of TGF beta RIII is found in higher grade lymphomas, and reduced expression of TGF beta RIII is found with advanced stage neuroblastomas and ovarian carcinomas. Low TGF-beta RIII expression also correlates with higher grade among a cohort of breast cancers. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis.