Recombinant Mouse TrkA (C-6His)

Description

EnkiLife provides the Recombinant Mouse TrkA (C-6His) protein,aslo know as NTRK1,NTRK-1,p140-TrkA,TRK1-transforming tyrosine kinase protein,TrkA,Trk-A,TRKAOncogene TRK,TRKTRK1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse High Affinity Nerve Growth Factor Receptor is produced by our Mammalian expression system and the target gene encoding Ala34-Pro418 is expressed with a 6His tag at the C-terminus.Accession:Q3UFB7. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:42.9 KDa. Background:TrkA (Tyrosine kinase receptor A), also known as High affinity NGF receptor, is a member of the neurotrophic tyrosine kinase receptor family that has three members. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Higher affinity binding of NGF requires the coexpression of TrkA with the p75 NGF receptor (NGFR), a member of the tumor necrosis factor receptor superfamily. Mutations in TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.