Recombinant Mouse TSLP R (C-6His)

Description

EnkiLife provides the Recombinant Mouse TSLP R (C-6His) protein,aslo know as CRL2,CRLF2,CRL2 cytokine receptor,Cytokine receptor-like 2,cytokine receptor-like factor 2,ILXR,IL-XR,P2RY8/CRLF2 fusion,Thymic stromal lymphopoietin protein receptor,Thymic stromal-derived lymphopoietin receptor,TSLP receptor,TSLPR, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Thymic Stromal Lymphopoietin Protein Receptor is produced by our Mammalian expression system and the target gene encoding Ala20-Leu233 is expressed with a 6His tag at the C-terminus.Accession:AAH23788.1. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:23.7 KDa. Background:The cytokine thymic stromal lymphopoietin receptor (TSLPR) is consisting of a common γ receptor–like chain (TSLPR-γ) and a common interleukin 7 (IL-7) Rα chain that belongs to the type 1 cytokine receptor family. Transfection of TSLPR cDNA result in only low affinity binding, while cotransfection of the IL-7Rα chain cDNA shows high affinity binding. TSLP and TSLPR play a critical role in the initiation of allergic diseases in mice. The TSLP R cDNA encodes a transmembrane receptor containing 370 amino acids (aa) with two potential N-linked glycosylation sites and a cytoplasmic domain of 104 aa including a single tyrosine residue. TSLPR can mediate signaling of the signal transducer and activator of transcription 5 (Stat5) by TSLP. TSLP R is broadly expressed in the immune and hematopoietic cells, particularly in hematopoietic progenitors and myeloid cells.