Recombinant Mouse VISTA (C-6His)

Description

EnkiLife provides the Recombinant Mouse VISTA (C-6His) protein,aslo know as Platelet receptor Gi24, stress induced secreted protein 1,Dies1,VISTA,SISP1,B7-H5,PD-1H;GI24, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Mouse Platelet Receptor Gi24 is produced by our Mammalian expression system and the target gene encoding Phe33-Ala191 is expressed with a 6His tag at the C-terminus.Accession:Q9D659. Expression Host:Human Cells.Species:Mouse.Predicted Molecular Mass:18.6 KDa. Background:Mouse Platelet receptor Gi24(VISTA) is a transmembrane glycoprotein with homology to B7like immune costimulatory molecules. Mature mouse Gi24 contains a 159 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane segment, and a 97 aa cytoplasmic domain. VISTA promotes both MT1-MMP expression and the MT1-MMP mediated activation of MMP-2. It supports the differentiation of embryonic stem cells (ESC) and enhances BMP-4 induced signaling in ESC, but it is also down-regulated following BMP-4 exposure. It binds to BMP-4 directly and also associates with the type I BMP receptor Activin RIB/ALK-4. It is expressed on the surface of naïve CD4+ T cells and regulatory T cells. It is up-regulated in vivo on activated monocytes and dendritic cells. VISTA inhibits CD4+ and CD8+ T cell proliferation and their production of IL-2 and IFN-γ. Its expression on tumor cells attenuates the antitumor immune response and enables more rapid tumor progression.