Recombinant Rat HER2 (C-6His)

Description

EnkiLife provides the Recombinant Rat HER2 (C-6His) protein,aslo know as Receptor tyrosine-protein kinase erbB-2,Epidermal growth factor receptor-related protein,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,p185erbB2,p185neu,CD340,ERBB2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Rat Receptor Tyrosine-protein Kinase ErbB-2 is produced by our E.coli expression system and the target gene encoding Ala67-Val323 is expressed with a 6His tag at the C-terminus.Accession:P06494. Expression Host:E.coli.Species:Rat.Predicted Molecular Mass:29.3 KDa. Background:ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. Rat ERBB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays a key role in development, cell proliferation and differentiation.