Recombinant Rat TNF alpha

Description

EnkiLife provides the Recombinant Rat TNF alpha protein,aslo know as Tumor Necrosis Factor,Cachectin,TNF-Alpha,Tumor Necrosis Factor Ligand Superfamily Member 2,TNF-a,Tumor Necrosis Factor,Membrane Form,Tumor Necrosis Factor,Soluble Form,Tnf,Tnfa,Tnfsf2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Rat Tumor Necrosis Factor is produced by our E.coli expression system and the target gene encoding Leu80-Leu235 is expressed.Accession:P16599. Expression Host:E.coli.Species:Rat.Predicted Molecular Mass:17.4 KDa. Background:Tumor necrosis factor alpha (TNF-alpha, TNFSF2) is the prototypic ligand of the TNF superfamily. Rat TNF-alpha consisits of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 179 aa extracellular domain (ECD). Within the ECD, rat TNF-alpha shares 94% aa sequence identity with mouse. TNF-alpha is produced by a wide variety of immune, epithelial, endothelial, and tumor cells. TNF exists as a homotrimer and interacts with SPPL2B. TNF is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. TNF is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes throught its effects on insulin resistance and fatty acid metabolism.