Recombinant Rhesus Macaque IFNAR1 (C-6His)

Description

EnkiLife provides the Recombinant Rhesus Macaque IFNAR1 (C-6His) protein,aslo know as alpha-type antiviral protein,AVP,beta-type antiviral protein,CRF2-1,Cytokine receptor class-II member 1,Cytokine receptor family 2 member 1,human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC,IFN-alpha/beta R1,IFN-alpha/beta receptor 1,IFN-alpha-REC,IFNAR,IFNAR1,IFN-aR1,IFNBR,IFNbR1,IFN-bR1,IFN-R-1, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Rhesus Macaque Interferon Alpha/Beta Receptor 1 is produced by our Mammalian expression system and the target gene encoding Ala25-Lys437 is expressed with a 6His tag at the C-terminus.Accession:XP_005548864.1. Expression Host:Human Cells.Species:Rhesus macaque.Predicted Molecular Mass:48.4 KDa. Background:Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.