Recombinant Rhesus Macaque LILRB1 (C-6His)

Description

EnkiLife provides the Recombinant Rhesus Macaque LILRB1 (C-6His) protein,aslo know as LILRB1,CD85j, ILT2, which features high purity, high activity, and high stability. It can be applied in scientific research, biopharmaceuticals, and other fields.Purity:Greater than 95% as determined by reducing SDS-PAGE;Endotoxin Level:<1 EU/µg as determined by LAL test.;Construction:Recombinant Rhesus Macaque LILRB1 is produced by our Mammalian expression system and the target gene encoding Ser17-His456 is expressed with a 6His tag at the C-terminus.Accession:F7H3G7. Expression Host:Human Cells.Species:Rhesus Macaque.Predicted Molecular Mass:48.5 KDa. Background:LILRB1, also known as CD85j and ILT2, is a transmembrane glycoprotein in the LILR immunoregulatory protein family. LILRB1 is expressed on NK cells that have expanded in response to acute HCMV infection. LILRB1 exhibits considerable diversity in the population, and polymorphisms in the LILRB1 gene have been associated with susceptibility to rheumatoid arthritis and weakly associated with HCMV disease in a subset of patients with HIV. The regulation of phagocytosis by macrophages is an additional key role of LILRB1 signaling. LILRB1 recognizes a wide variety of HLA haplotypes due to its interaction with the invariant β2M subunit of MHC class I, which suggests that this signaling axis is relevant across diverse patient populations.