(rel)-AR234960

Description

rel -AR234960 is a selective and competitive agonist of the G protein-coupled receptor MAS. rel -AR234960 binds to the MAS receptor to activate the downstream ERK1/2 signaling pathway, inducing the expression of connective tissue growth factor CTGF and its downstream collagen subtype genes such as COL1A1, COL3A1 . rel -AR234960 promotes collagen synthesis in cardiac fibroblasts through the MAS-ERK1/2-CTGF pathway and aggravates extracellular matrix remodeling. rel -AR234960s in vitro effect can be blocked by the MAS inverse agonist AR244555 and MEK1 inhibitor. rel -AR234960 regulates the expression of cardiac fibrosis-related genes and can be used in the study of heart failure.