RET Mouse Monoclonal Antibody

Description

EnkiLife offers the RET Mouse Monoclonal Antibody. This antibody reacts with Human species and is suitable for WB,IHC,ICC application. Alternative Names of Immunogen: Proto-oncogene tyrosine-protein kinase receptor Ret, Cadherin family member 12, Proto-oncogene c-Ret, Soluble RET kinase fragment, Extracellular cell-membrane anchored RET cadherin 120 kDa fragment, RET, CDHF12, CDHR16, PTC, RET51. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,IHC 1:100-1:500,ICC 1:20-1:50 Background: This gene, a member of the cadherin superfamily, encodesone of the receptor tyrosine kinases, which are cell-surfacemolecules that transduce signals for cell growth anddifferentiation. This gene plays a crucial role in neural crestdevelopment, and it can undergo oncogenic activation in vivo and invitro by cytogenetic rearrangement. Mutations in this gene areassociated with the disorders multiple endocrine neoplasia, typeIIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease,and medullary thyroid carcinoma. Two transcript variants encodingdifferent isoforms have been found for this gene. Additionaltranscript variants have been described but their biologicalvalidity has not been confirmed.