GENERAL CATALOGUE
RG-239
HY-177050 · 50 mg
MedChemExpress · Cat: HY-177050
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medchemexpress.com/rg-239.html
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Catalog No: HY-177050
CAS No: 1199222-56-4
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
RG-239 is an orally active TGR5 agonist with an EC50 of 120 nM, significantly outperforming Betulinic acid HY-10529 EC50 = 1.04 ?M . RG-239 demonstrates higher selectivity for TGR5 compared to the FXR?. RG-239 increases mitochondrial activity in adipocytes and promotes neurite outgrowth at higher concentrations. RG-239 inhibits LPS HY-D1056 -induced iNOS expression and nitrite production in Raw264.7 and microglia cells. RG-239 can be used for the study of type 2 diabetes 1 2 3 4 5 .
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