RIPK1-IN-33

Description

RIPK1-IN-33 is a blood-brain barrier-permeable and orally active RIPK1 inhibitor, with an IC50 of 0.115 ?M. RIPK1-IN-33 demonstrates remarkable anti-ferroptosis activity, radical scavenging capacity IC50 = 123.3 ?M , and anti-lipid peroxidation effects IC50 = 9.72 ?M . RIPK1-IN-33 markedly reduces cerebral infarction volume and improves neurological function scores in transient middle cerebral artery occlusion tMCAO model. RIPK1-IN-33 can be used for the study of ischemic stroke.