RIPK2-IN-8

Description

RIPK2-IN-8 is an orally active and highly selective RIPK2 inhibitor IC50 = 11 nM . RIPK2-IN-8 is highly selective for RIPK2 over RIPK1 IC50 30,000 nM and has a moderate inhibitory effect on RIPK3 IC50 = 44.61 nM . RIPK2-IN-8 inhibits the NOD2-RIPK2 signaling pathway and the expression of the inflammatory cytokines IL-6 and TNF?, thereby exerting anti-inflammatory effects. RIPK2-IN-8 has demonstrated anti-inflammatory and hepatoprotective effects in an acute liver injury ALI model and can be used in ALI research.