GENERAL CATALOGUE
RIPK3-IN-3
HY-149393 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-149393
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Catalog No: HY-149393
CAS No: 3052303-53-1
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
RIPK3-IN-3 compound 20 is a selective inhibitor of RIP kinase RIPK3 IC50=10 nM . RIPK3 mediates the phosphorylation of Mixed Lineage Kinase MLKL and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion.
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