GENERAL CATALOGUE
Ritlecitinib tosylate
HY-100754C · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-100754C
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medchemexpress.com/ritlecitinib-tosylate.htmlCatalog No: HY-100754C
CAS No: 2192215-81-7
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Ritlecitinib PF-06651600 tosylate is a highly selective, orally active, irreversible covalent JAK3 inhibitor IC50=33 nM without inhibitory activity towards JAK1, JAK2, and TYK2 IC50 10 ? M. Ritlecitinib tosylate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib tosylate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis AIA , and experimental autoimmune encephalomyelitis EAE .