GENERAL CATALOGUE
RK-582
HY-137849 · 5 mg
MedChemExpress · Cat: HY-137849
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Catalog No: HY-137849
CAS No: 2171388-28-4
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
RK-582 is an orally active, spiroindoline-based selective inhibitor of tankyrase. The IC50s of RK-582 against TNKS1/PARP5A and PARP1 are 36.1 nM and 18.168 nM, respectively. RK-582 inhibits rectal cancer COLO-320DM cells GI50=0.23 ?M and significantly inhibits tumor growth in a COLO-320DM mouse xenograft model.