RK-682 hemicalcium

Description

RK-682 hemicalcium is the hemicalcium salt form of RK-682 HY-135564A . RK-682 hemicalcium is the inhibitor for protein tyrosine phosphatase PTPase , heparanase, phospholipase A2 and HIV-1 protease. RK-682 hemicalcium inhibits the dephosphorylation of CD45 IC50 is 54 ?M and VHR IC50 is 2.0 ?M , and thereby inhibits the ERK signaling pathway. RK-682 hemicalcium inhibits the cell viability of cancer cell MGH-U3, T24 and UROtsa with IC50s of 78.2, 43.2 and 145 nM, respectively, arrests the cell cycle at G1/S phase, inhibits the cell migration and autophagy in MGH-U3 and T24 2 .