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RK-9123016
GENERAL CATALOGUE

RK-9123016

HY-111522 · 5 mg

MedChemExpress · Cat: HY-111522

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medchemexpress.com/rk-9123016.html
Catalog No: HY-111522
CAS No: 955900-27-3
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress

Description

RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC50 value of 0.18?AAasAasAAmuM but not other human sirtuin members including SIRT1 and SIRT3 at 100?AAasAasAAmuM. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A eIF5A , a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.

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