GENERAL CATALOGUE
RMC-5127
HY-173629 · 1 mg
MedChemExpress · Cat: HY-173629
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Manufacturer product page
medchemexpress.com/rmc-5127.htmlCatalog No: HY-173629
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
RMC-5127 is an orally active and brain-penetrant mutant-selective tri-complex RASG12V inhibitor. RMC-5127 non-covalently binds to cyclophilin A CypA , forming a binary complex that engages RASG12V ON to form a high-affinity tri-complex, sterically inhibiting RAS binding . RMC-5127 inhibits the RAS pathway in KRASG12V mutant cancer cells, reducing cell proliferation and inducing apoptosis. RMC-5127 is promising for research of cancers with RAS mutations, such as non-small cell lung cancer.
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