RN167 Rabbit Polyclonal Antibody

Description

EnkiLife offers the RN167 Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB,ELISA application. . The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,ELISA 1:5000-1:20000 Background: ring finger protein 167(RNF167) Homo sapiens RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008],function:May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition.,pathway:Protein modification; protein ubiquitination.,PTM:Auto-ubiquitinated in vitro in the presence of UBE2D1 and UBE2E1.,similarity:Contains 1 PA (protease associated) domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Targeted to cytoplasmic membranes.,subunit:Interacts with SLC22A18.,tissue specificity:Strongly expressed in the kidney and liver (at protein level).,