GENERAL CATALOGUE
RNF5 inhibitor inh-02
HY-123967 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-123967
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Catalog No: HY-123967
CAS No: 324579-65-9
Category: Metabolic Enzyme Protease
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
RNF5 inhibitor inh-02 is a potent inhibitor of E3 ubiquitin ligase RNF5/RMA1. RNF5 inhibitor inh-02 rescues F508del-CFTR function in F508del-CFTR-expressing immortalized cells CFBE41o?, EC50 = 2.6 ?M; FRT, EC 50 = 2.2 ?M . RNF5 inhibitor inh-02 increases LC3IIB expression and autophagic vacuole number via reducing ATG4B ubiquitylation and promotes cell motility. RNF5 inhibitor inh-02 can be used for the study of cystic fibrosis.
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