GENERAL CATALOGUE
Ro 31-8220
HY-13866A · 50 mg
MedChemExpress · Cat: HY-13866A
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medchemexpress.com/ro-31-8220.htmlCatalog No: HY-13866A
CAS No: 125314-64-9
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
Ro 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKC?, PKC?I, PKC?II, PKC?, PKC? and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3? IC50s, 3, 8, 15, and 38 nM, respectively , with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC.
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