GENERAL CATALOGUE
Ro 31-8220 mesylate
HY-13866 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-13866
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Manufacturer product page
medchemexpress.com/Ro-31-8220-mesylate.htmlCatalog No: HY-13866
CAS No: 138489-18-6
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKC?, PKC?I, PKC?II, PKC?, PKC? and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3? IC50s, 3, 8, 15, and 38 nM, respectively , with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC.
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