

HY-107506 · 1 mg
MedChemExpress · Cat: HY-107506
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medchemexpress.com/ro-67-4853.htmlDescription
Ro 67-4853 is a positive allosteric modulator PAM of mGluR1 pEC50=7.16 for rmGlu1a receptor . Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain TMD of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation.







