Ro 90-7501

Description

Ro 90-7501 is an amyloid ?42 A?42 fibril assembly inhibitor that reduces A?42-induced cytotoxicity EC50 of 2 ?M . Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 TLR3 and RIG-I-like receptor RLR ligand-induced IFN-? gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 PP5 in a TPR-dependent manner. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells.