GENERAL CATALOGUE
RO8994
HY-16999 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-16999
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medchemexpress.com/RO8994.html
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Catalog No: HY-16999
CAS No: 1309684-94-3
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
RO8994 Compound 4 is an orally active, highly potent and selective spiroindolinone p53-MDM2 inhibitor with an IC50 value of 5 nM HTRF binding assays and 20 nM MTT proliferation assays . RO8994 induces up-regulation of p53 expression and Apoptosis in wild-type p53 cancer cells. RO8994 also inhibits tumor growth in the tumor xenograft model.
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