GENERAL CATALOGUE
ROC-0929
HY-145384 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-145384
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Catalog No: HY-145384
CAS No: 1048660-43-0
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
ROC-0929 compound 13a is a potent and selective inhibitor of secreted phospholipases A2 sPLA2s with an IC50 of 80 nM, specially targeting hGX. ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38. Secreted phospholipases A2 sPLA2s are a family of disulfide-rich, Ca2+-dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases.
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