GENERAL CATALOGUE
ROCK/HDAC-IN-1
HY-168650 · 50 mg
MedChemExpress · Cat: HY-168650
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Manufacturer product page
medchemexpress.com/rock-hdac-in-1.htmlCatalog No: HY-168650
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
ROCK/HDAC-IN-1 Compound 10h is an orally active ROCK/HDAC inhibitor. ROCK/HDAC-IN-1 inhibits ROCK1/2 IC50: 254.9 nM, 58.18 nM and HDAC1/2/3/6/8 IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM . ROCK/HDAC-IN-1 stimulates the activation of DAMPs, specifically Calreticulin CRT exposure and HMGB1 release, indicating that it is a potential ICD inducer.. ROCK/HDAC-IN-1 has antiproliferative activity against breast cancer cells IC50: 0.37 ?M for MDA-MB-231 cell , and inhibits tumor growth and activates T cells without apparent toxicity.
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