ROR?/DHODH-IN-2

Description

ROR?/DHODH-IN-2 Compound 1311 is an orally active dual inhibitor of ROR?/DHODH with IC50 values of 11.9 nM and 90 nM, respectively. ROR?/DHODH-IN-2 exhibits antiviral activity by inhibiting the activity of SARS-CoV-2, HCMV, HAdV5, and MPXV, with IC50 values of 27 nM, 20 nM, 9.1 nM, and 1.8 nM, respectively.