ROR1-IN-3

Description

ROR1-IN-3 Compound 24d is a potent and highly selective ROR1 kinase inhibitor IC50 = 17.6 nM . ROR1-IN-3 demonstrates robust antitumor activity and inhibitory effect against ROR1 both in vitro and in vivo. ROR1-IN-3 has robust antiproliferative efficacy in vitro and in vivo. ROR1-IN-3 induces apoptosis in cancer cell lines. ROR1-IN-3 inhibits ROR1 downstream AKT/mTOR and NF-?B signaling pathway. ROR1-IN-3 can be studied in antitumor research.