Rosolutamide

Description

Rosolutamide ASC-JM17 , a curcumin analog, is an orally active, potent Nrf1 and Nrf2 activator. Rosolutamide activates Nrf1, Nrf2 and heat shock factor 1 Hsf1 , thereby activating the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. Rosolutamide degrades the polyglutamine polyQ androgen receptor AR via the ubiquitin-proteasome pathway and improves motor function in mouse models of spinal and bulbar muscular atrophy SBMA . Rosolutamide improves mitochondrial function and promotes autophagy, decreases mutant protein aggregates, and attenuates intracellular/mitochondrial reactive oxygen species ROS levels.