GENERAL CATALOGUE
Rosuvastatin
HY-17504A · 5 mg
MedChemExpress · Cat: HY-17504A
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Catalog No: HY-17504A
CAS No: 287714-41-4
Category: Anti-infection
Pack Size: 5 mg
Brand: MedChemExpress
Description
Rosuvastatin ZD 4522 is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks hERG current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations APDs and corrected QT interval QTc intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 Hsp70 with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein LDL cholesterol, triglycerides, and C-reactive protein levels.
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